Health benefits of dietary resistant starch, a non digestible fermentable glucose polymer

POLY 640

Michael J Keenan, mkeenan@lsu.edu1, Jun Zhou, zhouj@pbrc.edu2, Anne M Raggio, amraggio@agctr.lsu.edu1, Kathleen L McCutcheon, kmccutc@lsu.edu1, Richard T Tulley1, Maren Hegsted1, H Gale Bateman3, Ian Brown4, Anne Birkett5, Susan S Newman2, and Roy J Martin, rjmartin@lsu.edu2. (1) Human Ecology, LSU AgCenter, 209 Knapp Hall, Baton Rouge, LA 70803, (2) Neurobehavior, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, (3) Akey, (4) University of Wollongong, Australia, (5) National Starch and Chemical Company
Resistant starches (RS) reach the colon undigested and ferment to short chain fatty acids (SCFA). A gene array on rat cecal cells confirmed that numerous gene transcripts for endocrine, neural and immune proteins were increased by dietary RS and may affect health beyond the gut. Increased peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) were associated with reduced body fat. Cell culture indicated SCFA may cause increased gut hormones. Dietary RS improved glucose tolerance in mice with partial destruction of beta cell function. There are several reports of RS (in vivo) or gut hormones (in vitro) reducing tumors or inhibiting cancer growth. PYY and GLP-1 plasma levels were elevated compared to control when measured at several time points (24 hours). Pharmaceutical agents or gastric bypass surgery also increase gut hormones. Thus, dietary RS is a natural way to consistently elevate beneficial endogenous gut hormones.
 

Polymer Design for Foods and Nutrition
9:00 AM-11:40 AM, Thursday, August 23, 2007 Westin Boston Waterfront -- Grand Ballroom B, Oral

Division of Polymer Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007