Discovery of selective PDE7 and PDE7 and 4 dual inhibitors and their role in T cell activation

MEDI 263

William J. Pitts, pittsw@bms.com, Department of Chemistry, Bristol-Myers Squibb Research and Development, Route 206 and Province Line Rd, Princeton, NJ 08543
Based on a non-selective screening lead we have developed selective PDE7 inhibitors as well as a series of less selective compounds which inhibit both PDE7 and PDE4. Compounds were evaluated in a model of T cell proliferation as well as in a PDE7 knock out background in an effort understand the relative contributions of PDE7 and PDE4 to activity.
 

Phosphodiesterase Inhibitors
1:30 PM-5:00 PM, Wednesday, August 22, 2007 BCEC -- 213, Oral

Division of Medicinal Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007