ANYL 379 |
| Antibody microarrays are promising tools for candidate biomarker screening and disease diagnosis. The pathogenesis of pulmonary inflammatory diseases such as asthma is believed to involve the increased expression of a myriad of cytokines when a patient is in the acute disease state. We report the development of an antibody microarray that utilizes microsphere-based probes deposited in the etched face of an optical fiber bundle. We calibrated this array with recombinant cytokine standards and measured endogenous cytokine levels in saliva samples from patients with pulmonary inflammatory disease. This multi-cytokine microarray platform could be used to elucidate the causes of exacerbation and examine patient responses to treatment.
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Analytical Approaches
9:00 AM-12:00 PM, Wednesday, August 22, 2007 BCEC -- 104B, Oral
Division of Analytical Chemistry |
