INOR 761 |
| Elucidating a potential role for chromium in enhancing insulin sensitivity has been hindered by experimental problems. First, the pathway by which chromium is distributed in the body has not been fully elucidated. Additionally, chromium in tissues is found associated with an oligopeptide, LMWCr, which has been proposed to enhance insulin signaling by interacting with insulin receptor. However, LMWCr has proven difficult to structurally characterize and detect in biological matrices without radiolabeling. Thus, studies have been undertaken to develop and utilize procedures for analyzing chromium-containing macromolecules by mass spectrometry, most notably highly acidic peptides (including LMWCr) and their chromium complexes. This knowledge will be used to sequence LMWCr and related chromium-containing peptides and to detect these peptides in urine and other biological matrices. |
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Bioinorganic Chemistry: Enzymes and Coenzymes
7:00 PM-10:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster
Sci-Mix
Division of Inorganic Chemistry |