Chiral enrichment using ENS Polar Cationic SPE

ANYL 83

Daniel Sauerstrom, DSauerstrom@ensnano.com, Mike Kopczynski, mkopczynski@ensnano.com, and Regina Valluzzi, rvalluzzi@ensnano.com. R&D, ENS, 675 Massachusetts Ave, 14th Fl, Cambridge, MA 02139
With over 80% of current pharmaceutical development being chiral, there is an increased need for low-pressure chiral enrichment tools. In the early stages of drug discovery and development, the rapid screening of analytes becomes important. ENS Polar Cationic Solid Phase Extraction (SPE) cartridges provide a novel means for performing enrichments of these compounds.

The unique nature of the ENS stationary phase allows it universally enrich analytes across a wide range of compounds providing an advantage over the many molecular imprinted (MIP) extraction products that are typically designed to select for one analyte or analyte class. This ability to enrich analytes across multiple compound classes makes ENS Polar Cationic SPE cartridges extremely useful in a high throughput environment.

Data will be shown illustrating enrichment on an assortment of molecules including beta-andrenergic blocking agents (Beta Blockers), non-steroidal anti-inflammatory (NSAID) agents, chiral pesticides, amino acids and their derivatives.

 

General Posters
7:00 PM-9:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Sci-Mix

Division of Analytical Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007