PLGA/PVA hydrogel composites for long–term inflammation control on s.c. implantation of biosensor

COLL 62

Upkar Bhardwaj, upkar.bhardwaj@uconn.edu, Dept. of Pharmaceutics, University of Connecticut, 69 N eagleville Rd, Unit 3092, Storrs, CT 06269, Radha K Sura, radhakrishna.sura@uconn.edu, Department of Pathobiology and Veterinary Science, University of Connecticut, 61 N eagle ville Rd, Storrs, CT 06269, Fotios Papadimitrakopolous, FOTIOS.PAPADIMITRAKOPOULOS@uconn.edu, Dept. of Chemistry, University of Connecticut, 97 North Eagleville Road, Storrs, CT 06268, and Diane J. Burgess, d.burgess@uconn.edu, Department of Pharmaceutical Sciences, University of Connecticut, 69 N Eagleville RD, Unit 3092, Storrs, CT 06269.
Our previous studies have shown the feasibility of using PLGA microsphere/PVA hydrogel composites to deliver anti-inflammatory agents (e.g. dexamethasone) at an s.c. implant site to control inflammation for a period of one month1. The present work describes the development of composites capable of preventing inflammation and fibrosis for an implant life-time of three months. Composites were prepared using a mixed population of fast, medium and slow releasing microspheres. Composites were fabricated in 18G needles using PLGA microsphere/PVA (5% w/w) dispersions (three freeze-thaw cycles, -200C/240C and implanted s.c. in rats. The pharmacodynamic effect was evaluated by histopathological examination of excised tissue (stained with H&E). The composites were capable of controlling the tissue response for three months. These coatings would increase the functionality and life time of implantable devices such as glucose senors.

Acknowledgements: Financial support for this study was obtained through US Army Medical Research Grants (#, W81XWH-04-1-0779 and #W81XWH-05-1-0539).

1Patil et al. Diabetes Technol Ther. 2004;6(6):887-97.

 

Nanomaterials and Biological Applications: Diagnostic, Imaging, Biosensing and Drug Delivery
2:00 PM-5:15 PM, Sunday, August 19, 2007 BCEC -- 153C, Oral

Division of Colloid & Surface Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007