Demands of dermal delivery

COLL 332

J. Mark Chandler, mark.chandler@croda.com and Johann W. Wiechers, johann.wiechers@versatel.nl. Croda Inc, 315 Cherry Lane, New Castle, DE 19720
For success in the skin care marketplace, it is not enough to find a hard-working functional material or active ingredient and place it into a stable, aesthetically pleasing base. There is the serious threat that the material which has excellent label appeal and has performed so well on its own in early testing will be utterly worthless when placed in a stock emulsion. Money is wasted and consumers are disappointed. The approach to be presented is tailored to individual functional materials or active ingredients, encouraging effective delivery of these materials to the upper layers of the skin. Foundations of the system include selection of emulsion base ingredients that will bring the material into a particular phase of the formulation, and others that will subsequently drive the material from the formulation. Emulsifier system selection is then crucial to meeting the demands of dermal delivery.