Regulatory considerations for using disposable technologies in bioprocessing

BIOT 473

Antonio Moreira, Chemical and Biochemical Engineering, University of Maryland Baltimore County, Baltimore, MD 21250
Disposable technologies are becoming prominently used in the bioprocessing manufacturing industry by contract manufacturing organizations (CMOs) and for in-house manufacturing. This presentation will include a discussion of the regulatory issues and requirements concerning the use of disposable systems in biomanufacturing under CGMP compliance. A comparison of positive impacts (such as less intensive validation) and perceived increased burden (such as leachables/extractables issues and system integrity) will be addressed.