Double-headed nucleosides with thymine in the 2'-position

CARB 55

Charlotte Andersen, can@ifk.sdu.dk and Poul Nielsen, pon@ifk.sdu.dk. Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, Odense M, 5230, Denmark
An ODN with the double-headed nucleoside 2'-deoxy-2'-C-(2-(thymin-1-yl)ethyl)uridine has shown stabilizing ability towards both DNA:RNA and DNA:DNA duplex when arranged with the additional nucleobase in the branching point of tree way junctions. We wish to investigate if the stabilizing ability is dependent on the length and flexibility of the carbon-linker to the secondary nucleobase. We here present the synthesis of an analogue with a methyl-linker.

 

General Posters
6:00 PM-8:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Carbohydrate Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007