ANYL 437 |
| Continuous monitoring of glucose levels in human physiology is important for the long term management of diabetes. One such method for monitoring human glucose levels is to use “smart” holograms. “Smart” holograms utilise the principles of volume holography with a Denisyuk holographic grating recorded within a “smart” polymer. Unlike conventional holographic recording media, the “smart” polymers are rationally designed synthetic polymers incorporating phenylboronic acid receptor ligands, which are known to bind glucose reversibly. The interaction of our “smart” polymers with glucose causes the polymer to swell or contract which results in a change in the diffraction wavelength of the embedded hologram. A series of acrylamidophenylboronic acids have been synthesised and investigated as part of a structure activity relationship study to identify the most responsive and selective “smart” polymers for monitoring glucose levels in people with diabetes.
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Analytical Approaches
9:00 AM-12:00 PM, Thursday, August 23, 2007 BCEC -- 104A, Oral
Division of Analytical Chemistry |
