Synthesis and characterization of poly(N-isopropylacrylamide) particles in supercritical carbon dioxide

I&EC 69

Soyoung Kwon, kwon8@snu.ac.kr1, Kyoungwon Lee, kyoungwonlee@naver.com1, Kyoung Shil Oh, js6515@hotmail.com1, Won Bae, baewon@mwc.co.kr2, and Hwayong Kim, hwayongk@snu.ac.kr1. (1) Department of Chemical and Biological Engineering, Department of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, San 56-1, Shillim, Kwanak, Seoul, 151-744, South Korea, (2) R&D Institute, Miwon Commercial Co., Ltd, 405-3, Moknae-dong, Ansan-si, 425-100, South Korea
The temperature responsive poly(N-isopropylacrylamide) (PNIPPAm) have been widely used in biomedical applications, such as drug controlled release systems, drug carrier and so on. We carried out polymerization of N-isopropylacrylamide with AIBN as the initiator and N,N'-methylenebisacrylamide (MBIS) as the crosslinking agent using dispersion polymerization method in supercritical carbon dioxide. The polymerizations were prepared in scCO2 at various monomer concentration, temperature, pressure ranges and weights of crosslinking agent. Fluorinated and siloxane-based surfactants were used for spherical particles of NIPPAm in scCO2. The resulting polymer was characterized by FE-SEM, DSC, TGA and 1H-NMR etc.
 

IEC Poster Session
8:00 PM-10:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Industrial & Engineering Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007