MEDI 349 |
| Many metal complexes were found to be highly potent against various types of human cancer cells. However, clinical application of majority of anti-cancer metal complexes tested in vitro was hampered by lack of tumor specificity. One of promising approaches to overcome this limitation is targeted delivery of these anti-cancer metal complexes to tumor tissues. Anti-cancer copper complex is especially attractive for targeted cancer therapy because targeted delivery of anticancer copper complexes may be monitored non-invasively by positron emission tomography (PET) when positron emitting copper isotopes, such as copper-64, are used to radio-label the compound. In current study, 8-hydroxyquinoline was coupled to 2-carboxaldehyde–thiosemicarbazide to make 8-hydroxyquinoline-2-carboxaldehyde–thiosemicarbazide (HQTS) holding a unique ONNS quadridentate system. The HQTS-copper complex suppressed proliferation and induced apoptosis of human neuroblastoma and malignant glioblastoma cells. The CuHQTS complex holds potential for targeted cancer therapy monitored by PET imaging. |
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Poster Session
7:00 PM-9:00 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Medicinal Chemistry |