Synthesis and characterization of pyrrolidine dithiocarbamate-copper complex: Proliferation inhibition, cell cycle arrest, apoptosis induction activities on cisplatin-resistant neuroblastoma cells

MEDI 346

Haiyuan Zhang, hazhang@med.wayne.edu and Fangyu Peng, fpeng@pet.wayne.edu. Pediatrics and Radiology, School of Medicine, Wayne State University, 4901 Beaubien Blvd, Detroit, MI 48201
Neuroblastoma (NB) is a malignant tumor originated from the peripheral sympathetic nervous system in children. Despite initial response to induction chemotherapy, acquired resistance to conventional chemotherapeutic drugs such as cisplatin and carboplatin is rapidly developed which is one of major causes of treatment failure in many patients. New effective drugs are urgently needed for treatment of those children suffering refractory NB. Pyrrolidine dithiocarbamate (PDTC) is a copper-binding ligand which was reported to have strong anti-tumor activity on many human tumor cells highly resistant to conventional chemotherapeutic agents. In current study, PDTC copper complexes (Cu-PDTC) were synthesized and showed strong anticancer activity against BE(2)C cells, a human neuroblastoma cell line highly resistant to cisplatin. The data from this study suggest that the CuPDTC complex holds potential to be used for treatment of refractory neuroblastoma in children.
 

Poster Session
7:00 PM-9:00 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Medicinal Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007