INOR 264 |
| Hybrid nanoparticles containing a luminescent core and a chelated Gd(III) paramagnetic coat were prepared using reverse microemulsion methods, and characterized by a variety of techniques including SEM, TEM, zeta potentiometry, TGA, and direct current plasma spectroscopy. These nanoparticles exhibit extraordinarily high MR-relaxivities as a result of high Gd(III) loading and reduced tumbling of the immobilized Gd chelates on the nanoparticles. The hybrid nanoparticles are thus excellent multimodal contrast agents for both MR and optical imaging. An electrostatic layer-by-layer self-assembly strategy was used in conjunction with Gd(III)-chelate polyelectrolyte building blocks to control nanoparticle size, magnetic resonance relaxivities, and biological targeting. In vitro labeling of cancer and angiogenesis by functionalized nanoparticles has been achieved. Preliminary in vivo data indicate that these hybrid nanoparticles are excellent contrast agents for imaging choroid plexus carcinoma and inflammatory arthritis in mouse models. |
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Nanoscience: Applications
7:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Inorganic Chemistry |