INOR 197 |
| Gadolinium complexes have been widely used as MRI contrast agents, utilizing DO3A or DTPA as a ligand to form octa-coordinate chelates. The use of macrocyclic ligands in the synthesis of these complexes guarantees both thermodynamic stability and kinetic inertness, requirements for the design of non-toxic in vivo imaging agents. Other lanthanide complexes have been shown to exhibit long-lived luminescence when their excited states are populated by a π→π* transition of an appended chromophore. Photophysical properties of these complexes can be improved by increasing the number of emitting centres, and by “tuning” the chromophore to absorb at longer wavelengths. Here we report the synthesis of polymetallic lanthanide complexes, and the incorporation of an azo dye as a sensitiser. Strategies for the synthesis of polyheterometallic f-f' hybrids are also presented, leading towards the development of agents both MRI-responsive and exhibiting visible/NIR luminescent behaviour.
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Chemistry of Lanthanides and Actinides
7:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Sci-Mix
Division of Inorganic Chemistry |
