Insights into the setup of the GSK docking evaluation

COMP 150

Neysa Nevins, Neysa.2.Nevins@gsk.com, Computational and Structural Sciences, GlaxoSmithKline, 709 Swedeland RD, UW2940, King of Prussia, PA 19046 and Martha S Head, Martha.S.Head@gsk.com, Computational and Structural Sciences, GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, UP-1110, Collegeville, PA 19426.
Preparing to run a molecular modeling software evaluation requires tremendous thought upfront. For a docking and scoring evaluation, choice of protein targets, compound sets, target and ligand preparation, software user experience, and data analysis will all affect the outcome of the study. This talk will detail how the GSK docking and scoring evaluation was carried out, with attention given to the variables mentioned. Changes were implemented as the study progressed, and the rationale for the initial setup and subsequent study modifications will be discussed.