Analysis of nitrofuran residues in shrimp, channel catfish, and milk using liquid chromatography-tandem mass spectrometry

AGRO 13

Pak-Sin Chu1, Mayda I. Lopez1, Ann Abraham2, Kathleen R. El Said2, and Steven M. Plakas2. (1) Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, (2) Gulf Coast Seafood Laboratory, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 1 Iberville Drive, Dauphin Island, AL 36528
Nitrofuran drugs are effective in treatment and control of bacterial and protozoan infections in humans and animals. Because of their mutagenicity and carcinogenicity, nitrofurans have been banned for use in food-producing animals in many countries. Our laboratory has developed and validated methods for determining the side chains of the nitrofuran drugs furazolidone, nitrofurazone, furaltadone, and nitrofurantoin in several food products. As part of the method validation, we have also conducted nitrofuran incursion studies in food animals and measured residues in various matrices. Here, we describe and compare the incursion profiles of nitrofuran residues in shrimp and channel catfish muscle tissue and in cow milk. In these matrices, nitrofurantoin exhibits the lowest level of residues among the four nitrofurans.
 

Agrochemical Residue & Metabolism Chemistry
8:55 AM-11:20 AM, Sunday, August 19, 2007 BCEC -- 259B, Oral

Division of Agrochemicals

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007