ANYL 116 |
| The number of reports on new techniques in molecular imaging has been recently increasing because of their usefulness in biological, medical, and clinical research. Fluorescence imaging methods are generally superior in terms of sensitivity, selectivity and ease of use. Cyanine dyes have been employed as fluorescent labels in fluorescence imaging studies of biological mechanisms. In particular, tricarbocyanines have the advantage that light at their emission and absorption maxima in the near-infrared region around 650-900 nm is relatively poorly absorbed by biomolecules, and so can penetrate deeply into tissues. We successfully developed cyanine probes for nitric oxide1) and zinc ion. 2) We have recently developed several pH probes based on the amine-substituted tricarbocyanine fluorophore. We could measure pH with these fluorescent probes by ratiometric monitoring methods. 1) E. Sasaki et al. J. Am. Chem. Soc. 127, 3684 (2005). 2) K. Kiyose et al. J. Am. Chem. Soc. 128, 6548 (2006). |
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General Posters
7:00 PM-9:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Analytical Chemistry |