INOR 613 |
| Galactose oxidase is a fungal enzyme that catalyses the oxidation of a number of substrates to the corresponding aldehydes along with the reduction of dioxygen to hydrogen peroxide. The sugar galactose is oxidised to galactohexadialdose. The active site in Galactose oxidase contains a copper atom bonded to two tyrosine oxygen atoms, two histidine nitrogen atoms and a water molecule in the inactive form of the enzyme. We have synthesised a series of copper(II) compounds of tridentate NNO ligands formed by the Schiff base condensation of salicylaldhydes with N,N dialkylethylenediamines of the type CuL.B.ClO4 These compounds can be oxidised with Ce4+ to form unstable radical species. We have used electrospray mass spectrometry to show that the copper compounds oxidise galactose to the corresponding aldehyde in methanol solution in the presence of sodium hydroxide. |
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Inorganic Modeling of Biological Systems
7:00 PM-10:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster
Sci-Mix
Division of Inorganic Chemistry |