COLL 61 |
| Hydrodynamic flow focusing is a seminal and easy to use technology enabling the generation of monodisperse droplets in a single step fashion. Using a polymer solution and various active components (drugs), hydrodynamic flow focusing gives rise to generate tailored monodisperse microspheres for pharmaceutical and life science applications (e.g., drug targeting) at low costs and high efficiency. So far only the successful encapsulation of fluorochrome dyes into non-biodegradable microspheres was reported using hydrodynamic flow focusing. Here we present a comprehensive parameter study to optimize the flow focusing process resulting in a dispersity of as low as 6% C.V. Furthermore, we present the encapsulation of the anti-cancer drug camptothecin in biodegradable poly(D,L-lactide-co-glycolide-acid) and poly(lactic-acid) microspheres (median 1.5 to 2.0 µm, C.V. = 14%) and a drug load of up to 0.65 wt% per polymer weight. Our studies showed continuous drug release in vitro over a period of 14 days. |
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Nanomaterials and Biological Applications: Diagnostic, Imaging, Biosensing and Drug Delivery
2:00 PM-5:15 PM, Sunday, August 19, 2007 BCEC -- 153C, Oral
Division of Colloid & Surface Chemistry |