Progress toward a chemical code for targeting RNA

CARB 16

Matthew D. Disney, mddisney@buffalo.edu, Department of Chemistry, Center for Excellence in Bioinformatics & Life Sciences and Department of Chemistry, University at Buffalo, State University of New York at Buffalo, Buffalo, NY 14260
RNA is an important drug target whose potential has been largely unexplored. We will describe our efforts towards developing a set of rules to enable the facile and reliable design of small molecules targeting RNA. These efforts describe the development of an RNA motif-ligand database.