Preparation of metal oxide nanocrystals in aqueous solution and their biocompatibility

ANYL 455

Aiguo Wu, aiguo@northwestern.edu, Koshonna Brown, Kenneth T. Thurn, Tatjana Paunesku, and Gayle E. Woloschak, g-woloschak@northwestern.edu. Departments of Radiation Oncology, Radiology,Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Ave, Ward-13-007, Chicago, IL 60611
We report a green chemistry preparation method for metal oxide nanocrystals in aqueous solution. Two nanometer (non-)magnetic nanocrystals of Alpha-Fe2O3, and CoFe2O4; 3 and 6 nm TiO2 nanocrystals; ~30 nm of Alpha-Fe2O3@TiO2 core-shell nanocrystals; and 6 nm CoFe2O4@TiO2 magneto-optical core-shell nanocrystals were prepared in aqueous solution in air around room temperature. The TEM data confirmed sizes of these nanocrystals. We tested biocompatibility in cultured cells and conjugated DNA oligonucleotides or peptides to some of these nanocrystals. 2D elemental maps of cells transfected by nanoconjugates showed intracellular distribution of these nanoparticles.
 

Analytical Approaches
1:30 PM-4:30 PM, Thursday, August 23, 2007 BCEC -- 104C, Oral

Division of Analytical Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007