Redox regulation of protein tyrosine phosphatase 1B function by an organic peroxide:

TOXI 104

Sanjib Bhattacharyya, sby87@mizzou.edu, Chemistry, University of Missouri Columbia, 601 south college ave, Columbia, MO 65211 and Kent S Gates, GatesK@missouri.edu, 601 south college ave, University of Missouri Columbia, Columbia, MO 65211.
Redox Regulation of Protein Tyrosine Phosphatase 1B function by an organic peroxide:

Protein tyrosine phosphatases (PTPs) play a central role in the regulation of various signal transduction pathways. The intracellular signaling agent hydrogen peroxide regulates the activity of PTPs via oxidation of the active site cysteine residue. Subsequent reaction of the oxidatively-inactivated enzyme results in regeneration of the active enzyme. Here, we report the first example of redox inactivation of a PTP by organic hydroperoxides.

 

Poster Session and Awards
6:00 PM-10:00 PM, Tuesday, August 21, 2007 BCEC -- 204 A/B, Poster

Division of Chemical Toxicology

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007