Releasing of nitric oxide from elastic electrospun nanofibers

MEDI 129

Piyaporn Kampeerapappun, pk12@uakron.edu1, Marcos Lopez, marcoslopez@mcw.edu2, Patricio Lopez-Jaramillo, jplopezj@hotmail.com3, and Daniel J. Smith, djs5@uakron.edu1. (1) Department of Chemistry, The University of Akron, 190 Buchtel Commons, Akron, OH 44325, (2) Free Radical Research Center and Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, (3) VILANO Group, Cardiovascular Foundation of Colombia, Research Institute, 155 A St No 23-58 El Bosque, Floridablanca, Colombia
In general, nitric oxide is known to exert beneficial results related to an adequate healing due to its antibiotic and vasodilatory effects. For this purpose, we have developed a multilayer transdermal electrospun wound dressing which allows the controlled release of nitric oxide from a NO2-/ascorbic acid system encapsulated in polymer nanofibers. Using this approach, a wound dressing capable of delivering micromolar NO/cm2 for 6 h and 24 h at 37 C has been successfully produced and it can maintain its activity after sterilization procedures. Double-blind clinical trials were performed to determine the efficacy of the nitric oxide releasing patch (NOP) in treating diabetic foot ulcers (DFU). Results confirm that with daily application, a complete re-epithelization, development of fibrous tissue and recovery of sensitivity in the affected area is obtained within months.
 

Poster Session
7:00 PM-9:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Medicinal Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007