Bioavailability, distribution and clearance of cranberry flavonol glycosides

AGFD 6

Nicholi Vorsa, vorsa@aesop.rutgers.edu1, Ajay P. Singh, singh@aesop.rutgers.edu2, Elena Shabrova, shabrova@aesop.rutgers.edu3, Karen M. Schaich, schaich@aesop.rutgers.edu3, Hong Jin, hjingad652003@yahoo.com2, and Loredana Quadro3. (1) Department of Plant Biology and Philip E. Marucci Center for Blueberry & Cranberry Research & Extension, Rutgers University, 125 Lake Oswego Rd., Chatsworth, NJ 08019, (2) Plant Biology, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901, (3) Dept. of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901-8520
Bioavailability of glycosylated flavonoids is thought to be influenced by sugar moiety specificity. We evaluated the bioavailability, metabolism and distribution of the main cranberry flavonol glycosides administered via oral gavage in mice. Quercetin-3-galactoside (Q-3-gal), quercetin-3-glucoside (Q-3-glc), and their putative metabolites were specifically compared in plasma, liver, and kidney over time, post-administration. Q-3-gal plasma levels reached a Cpmax at 7.5 minutes while Q-3-glc peaked at 15 min. In contrast to Q-3-glc, Q-3-gal and other cranberry quercetin glycosides appear to be metabolized to a lesser degree, both quantitatively and qualitatively. Cranberry flavonols administered by intraperitoneal injection (IPI) exhibited fast clearance from serum, high uptake by liver and kidney and rapid excretion in bile. Elevated concentrations of flavonols and their metabolites found in bladder and urine, administered orally or by IPI, suggests a potential mechanism for the beneficial effects of cranberry towards urinary tract health.
 

Characterization and Bioavailability of Flavonoid Glycosides
8:00 AM-12:10 PM, Sunday, August 19, 2007 BCEC -- 255, Oral

Division of Agricultural & Food Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007