MEDI 39 |
| Melanin concentrating hormone (MCH) is a 19 membered neuropeptide that is found in the lateral hypothalamus and regulates food intake. There is evidence for involvement of MCH in feeding and obesity. Hypothalamic MCH peptide levels increase during fasting in ob/ob and WT mice. ICV administration of MCH or analogs stimulates feeding in rodents and MCH-/- mice, while otherwise healthy, are hypophagic and leaner than WT mice. MCH receptor knock-out mice are lean, hypophagic, hyperactive, have reduced fat mass, have increased metabolic rate and they are resistant to diet induced obesity (DIO). Evidence from knock-outs suggests an MCH receptor antagonist should be beneficial for treatment of obesity and related disorders. Discovery of a new class of small molecule MCH-R1 antagonists will be discussed.
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Poster Session
7:00 PM-9:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Medicinal Chemistry |
