FLUO 21 |
| Improving the biological and pharmaceutical properties of drug candidates by site-specific structural modifications is one of the main goals in medicinal chemistry. In this context the introduction of fluorine has proven to be one of the most successful concepts. Our research focuses on the development of appropriate peptide based model systems, which provide the ability to study the properties of fluorine as an amino acid side chain function in native protein environments. Using these model peptides we investigate the proteolytic stability of fluorine substituted peptides and are able to interpret the results in terms of non-covalent interactions of those peptides with enzymes. Another model system serves as a tool to study the effects of fluorine on the kinetics and thermodynamics of peptide self assembly applying SPR. With the help of this system we screen for preferred native binding partners of fluorinated amino acids using phage display. |
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Nanostructured Fluorocarbons: Smart Tectons for Self-Assembly
2:00 PM-4:25 PM, Monday, August 20, 2007 BCEC -- 252B, Oral
Division of Fluorine Chemistry |