Frontiers in chemical toxicology: An editor's perspective

TOXI 24

Lawrence J. Marnett, larry.marnett@vanderbilt.edu, Department of Chemistry, Center in Molecular Toxicology and the Vanderbilt-Ingram Cancer Center, Vanderbilt University, 850 A Robinson Research Building, Nashville, TN 37232-0146
Chemical toxicology has made tremendous strides over the past twenty years in parallel to advances in analysis, synthesis, and mechanism. These advances have provided the tools for placing toxicological phenomena on a quantitative basis. Chemical approaches will be applied to increasingly complex biological problems including disease mechanisms, low-dose risk assessment, the interplay of exposure to exogenous and endogenous toxicants, and the complete inventory of cellular responses to chemical stress inter alia. Increasingly, quantitative approaches will be applied to human populations to identify individuals at-risk of adverse outcomes. This presentation will highlight several examples of emerging problems and opportunities and the role that chemists will play in their evolution.