BIOT 239 |
| Over the last few years, Centocor has been developing a disposable bioreactor system for use in the Development and GMP Pilot Plant Facilities. The project began internally at the 50 L scale, and through collaboration with Hyclone, evolved to a GMP compliant 1000 L bioreactor. Initially, a set of design requirements was established to ensure scalability, and adequate mass transfer and mixing to support cell growth. At each stage of the project, the disposable bioreactors were able to achieve growth and productivity comparable to stainless steel bioreactors. However, several issues and design limitations were encountered which required practical solutions to improve usability and safety, and meet GMP requirements. This presentation will summarize these development efforts, and highlight some of the challenges and solutions which resulted in a fully GMP compliant 1000 L disposable bioreactor system. |
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Poster Session
5:30 PM-7:30 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Biochemical Technology |