More biocompatible glucose biosensors via nitric oxide-releasing silica nanoparticles

ANYL 333

Mark H. Schoenfisch1, Heather Egolf-Fox1, Jae Ho Shin2, and Evan M. Hetrick2. (1) Department of Chemistry, University of North Carolina at Chapel Hill, CB# 3290, Chapel Hill, NC 27599-3290, (2) Department of Chemistry, University of North Carolina at Chapel Hill, CB# 3290, Chapel Hill, NC 27599-3290
Designing in vivo biosensors for real-time monitoring of glucose remains a significant challenge due to poor biocompatibility resulting from the inflammatory response, bacterial infection, and fibrous capsule formation around the sensor. Several strategies have been explored to improve the biocompatibility of such devices including the use of nitric oxide (NO)-releasing coatings. NO plays a key role in numerous physiological processes including immune response and wound healing. In previous work, we synthesized NO-releasing sensor coatings via amine-functionalized xerogel films and discovered an unexpected reduction in analyte permeability and sensor response. Herein, we describe the use of NO-releasing silica nanoparticles doped into polyurethane to fabricate NO-releasing glucose sensor membranes. In addition to biosensor fabrication, the properties of silica nanoparticles as NO release vehicles and the attributes of the NO-releasing polyurethane as biocompatible membranes are presented.
 

ACS Award in Analytical Chemistry in Honor of James W. Jorgenson
8:30 AM-12:00 PM, Tuesday, August 21, 2007 BCEC -- 104C, Oral

Division of Analytical Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007