COLL 333 |
| The organization and molecular dynamics of the various lipid components within the stratum corneum is of critical importance to healthy skin barrier function. However, the complexity of the stratum corneum membrane, and the large number of lipid species it contains, make it a very difficult system to study in situ. One solution to this problem is to employ model lipid membranes. By using well designed membrane models, ranging form one component membranes to ternary ceramide, fatty acid and cholesterol membranes, it is possible to ask specific questions about lipid organization and dynamics, and thereby shed light on lipid behavior in the intact skin barrier. In this presentation I will discuss using biophysical IR spectroscopic methods to study membrane models of the skin barrier and describe the information gained from such approaches, including the presence of orthorhombic lipid domains and the correlation between molecular organization and skin barrier permeability. |
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Surfactants and Polymers for Personal, Home and Health Care
9:00 AM-11:45 AM, Tuesday, August 21, 2007 BCEC -- 152, Oral
Division of Colloid & Surface Chemistry |