A novel antifungal agent ilicicolin H produced by Fusarium sp. F-4

AGRO 76

Chen Deng1, Yang Dong Chen1, Zhi Yu Shao1, and Feng Hong, fhong@dhu.edu.cn2. (1) Donghua University, Shanghai 201620, China, (2) Institute of Biological Sciences and Biotechnology, Donghua University, Ren Min North Road No.2999, Shanghai 201620, China
Ilicicolin, a potent antifungal agent, was found first in Cylindrocladium ilicicola MFC-870 in 1971 and was classified from A to H. This study is the first to report that ilicicolin H could be separated from the metabolites of an endophytic fungus Fusarium sp. F-4, which was isolated from a seagrass Spartina alterniflora. The composition of cultural medium and the cultural conditions of Fusarium sp. F-4 were optimized using single-factor tests and an orthogonal experiment in shake-flask cultivations to improve the yield of ilicicolin H. Several impact factors including carbon sources, nitrogen sources, precursors of ilicicolin, initial pH of medium, temperature, and rotational speed were investigated. The growth curve after optimization showed that the culture finished in 120 h.
 

New Developments and Issues in Agrochemical Sciences
8:00 AM-11:00 AM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Sci-Mix

Division of Agrochemicals

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007