ANYL 113 |
| Luminescent lanthanide complexes that emit near-infrared (NIR) luminescence have been attracting growing attention as a tool to probe biological systems because they possess several advantages over conventional organic fluorophores, including long luminescence lifetimes (microseconds), remarkable transparency of biological tissues to emission light, and large Stokes shifts. However, as far as we are concerned, most of the complexes reported so far are too dark for practical use in aqueous solution. Evidently, the development of highly-visible complexes is required. We report here that DTPA complexes of Nd and Yb, conjugated to boron-dipyrromethene (BODIPY) dyes, can be strongly luminescent even in aerated water, compared with previously reported complexes. Furthermore, by introducing a pH-sensitive aromatic amino group into a complex, we successfully developed the first “long-lived NIR luminescence probe” for pH. The probe exhibits strong NIR luminescence in acidic solution, while the luminescence is quenched by photoinduced electron transfer (PeT) process in basic solution. |
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General Posters
7:00 PM-9:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Analytical Chemistry |