Cytotoxicity of mesoporous silica nanomaterials

INOR 269

Anthony J. Di Pasqua1, Krishna K. Sharma, kksharma@syr.edu1, Yan-Li Shi, yashi@syr.edu1, Bonnie B. Toms2, James C. Dabrowiak, jcdabrow@syr.edu1, and Tewodros Asefa, tasefa@syr.edu1. (1) Department of Chemistry, Syracuse University, 111 College Pl, CST 1-014, Syracuse, NY 13244-4100, (2) Department of Pediatrics, Upstate Medical University, State University of New York, 750 E. Adams St., Syracuse, NY 13210
With the rapidly growing interest in the use of mesoporous nanomaterials for drug delivery and other biological applications, it is important to measure the cytotoxic effects of these materials toward human cell lines. We here study the cytotoxicity of non-, mono- and bi-functionalized mesoporous silica and, for comparative purposes, silica toward human neuroblastoma (SK-N-SH) cells. The mesoporous materials were characterized using TGA, TEM, XRD, N2 gas absorption and solid-state NMR spectroscopy. How cell viability and growth, determined by trypan blue staining, are affected after 48 hours of direct exposure to these materials, as a function of their surface area and the nature of their functional groups, will be presented.
 

Nanoscience: Applications
7:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Inorganic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007