ORGN 481 |
| Liposome has been used as a vehicle to encapsulate chemotherapeutic agents for delivering to disease cells. Although such a delivery system has the potential to decrease the toxic side effects often associated with conventional small-molecule chemotherapy, successes have been limited to date due to the intrinsic instability of liposomes and the lack of specific triggers that can release the encapsulated drug at the disease site. To overcome these challenges, drug-encapsulated liposomes were first grafted to a cholesterol-functionalized poly(acrylic acid) additive via a simple drop-in procedure (see Figure). The resulting polymer-grafted liposomes possess surface-active carboxylate groups that can be crosslinked with telechelic poly(ethylene glycol) diamine linkers to afford highly stable Polymer-Caged Liposomes (PCLs). The cross-linked polymer cage in PCL acts as a lyoprotectant for the liposome core underneath, allowing for long-term storage of virtually any liposome sample as dry powders that can be reconstituted at will. It also greatly enhanced the stability of the caged liposome core in blood serum by virtue of steric barrier. Most importantly, the pH-responsive characteristics of the cross-linked polymer-cage can be used to trigger the release of the encapsulated drug payloads under specific acidic conditions.
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Physical Organic Chemistry, Metal-Mediated Reactions, Asymmetric Reactions and Syntheses
8:00 PM-10:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |
