ORGN 175 |
| Colorimetric sensors that translate molecular recognition into a visual signal are practical and convenient due to the facile nature of the readout measurement. Molecular cleft receptors are known to bind guests based on hydrogen bonding and aryl stacking interactions and these features suggest that they can be used in colorimetric sensors for aromatic guests of complementary size, shape, and functionality. This concept has been investigated in our laboratories as we sought to visually detect various electron rich aromatic alcohols. Cleft receptor 1, which is accessible in three steps, was designed to have an electron deficient diimide platform and two arms that possess substituted pyridine units whose nitrogens are suitable for hydrogen bonding with guests. The binding affinity and selectivity for aromatic alcohols and diols with 1 will be presented.
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Total Synthesis, Materials, Devices and Switches, Molecular Recognition and Self-Assembly, Biologically-Related Molecules and Processes
8:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |
