DNA Strand cleavage near at mismatch directed by a rhodium complex

INOR 154

Mi Hee Lim, mhlim@caltech.edu and Jacqueline K. Barton. Division of Chemistry and Chemical Engineering, California Institute of Technology, M/C 127-72, 1200 East California Boulevard, Pasadena, CA 91125-7200
Malfunctions in the DNA mismatch repair machinery result in DNA damage that lead to irreversible mutations and cancer. We have developed a series of rhodium(III) complexes that target a range of single base DNA mismatches. The use of those Rh complexes in diagnostics and therapeutics are limited since the complexes promote strand cleavage only with photoactivation. As an alternative, we have incorporated an oxidative cleavage functionality into the rhodium [Rh(chrysi)]3+ (chrysi = 5,6-chrysenequinone diimine) platform to trigger DNA cleavage without light activation. Here, we present the preparation and characterization with DNA of the Rh(III)-Cu(I) conjugate.

 

Bioinorganic Chemistry: DNA and RNA
1:30 PM-5:30 PM, Sunday, August 19, 2007 BCEC -- 211, Oral

Division of Inorganic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007