ORGN 124 |
| Transcription is the first committed step in gene expression, and is tightly regulated by the action of activators and repressors. Diseases are often characterized by aberrant gene expression profiles, and restoring these to their proper levels hold therapeutic promise. We have identified new small molecule scaffolds that activate transcription in mammalian cells. This new repertoire of small molecule activation domains will allow for the potential to target specific cell-types and activator-coactivator complexes. The results of a cellular small molecule screen in S. cerevisiae and human mammalian cells will be described. |
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Total Synthesis, Materials, Devices and Switches, Molecular Recognition and Self-Assembly, Biologically-Related Molecules and Processes
8:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |