Solution behavior of an octabrominated gadolinium porphyrin

CHED 263

Jack H. Owens Jr., jack_owens@ecats.gcsu.edu, Department of Chemistry and Physics, Georgia College & State University, CBX 082, Milledgeville, GA 31061 and Rosalie A. Richards, rosalie.richards@gcsu.edu, Department of Chemistry & Physics, Georgia College & State University, CBX 082, Milledgeville, GA 31061.
The field of photodynamic therapy (PDT) holds potential for treatment of tumors and yeast infections through less invasive methods than current treatments. Porphyrins are good candidates for PDT as they readily develop singlet oxygen. The addition of contrast agents to induce selective uptake is of great interest. Gadolinium complexes have been used extensively as contrast agents as well as PDT agents using porphyrin derivates such as Texaphryn. A novel octabrominated gadolinium porphyrin has been synthesized and is stable, electron deficient, and saddle-shaped. The ligand binding effects of this gadolinium porphyrin were investigated using monodentate ligands. Spectroscopic findings will be presented.
 

Undergraduate Research Poster Session
2:30 PM-4:30 PM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Chemical Education

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007