ORGN 136 |
| Our lab has developed cyclic bis-amino acid building blocks that are stitched together to form spiro-ladder oligomers with programmable shapes. By choosing different combination of monomers with varying stereochemistry, we have synthesized a large number of scaffolds with different shapes. However these scaffolds can carry functional groups only at the ends, thus limiting our ability to use these for variety of applications. Herein we report the synthesis of a bis-amino acid carrying an acetyl group as the side chain. Using similar methodology we are synthesizing other building blocks with side chains displaying diverse functional groups. With the introduction of these new functionalized building blocks we shall be able to display the desired functionality at desired positions on oligomers and control their relative orientation in three-dimensional space. This will allow us to explore rational design of molecular recognition and biomimetic catalysis.
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Total Synthesis, Materials, Devices and Switches, Molecular Recognition and Self-Assembly, Biologically-Related Molecules and Processes
8:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Sci-Mix
Division of Organic Chemistry |
