ORGN 388 |
| The desymmetrization of achiral molecules is powerful strategy for the synthesis of optically active materials. The conversion of simple precursors into functionalized products is a continuing goal in chemistry to efficiently access complex architectures for use in total synthesis and medicinal chemistry. An especially challenging stereogenic motif in organic chemistry is a quaternary carbon center. Chiral N-heterocyclic carbenes (NHCs) are highly selective catalysts for the intramolecular aldol reaction of the 1,3-diketones to afford optically active cyclopentene compounds after decarboxylation of bicyclic lactone intermediates. The scope and details of the reaction will be presented.
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Asymmetric Reactions and Syntheses
8:00 AM-12:00 PM, Tuesday, August 21, 2007 BCEC -- 253C, Oral
Division of Organic Chemistry |
