ORGN 666 |
| The azaphilones are a diverse family of natural products which exhibit a wide range of biological activities, including p53/MDM2 binding and fatty acid synthase inhibition. The varied structures of these molecules are the result of a wide range of biosynthetic modifications. Herein, we outline our approach towards the synthesis of azaphilone natural products, including the epoxide-containing fatty acid synthase inhibitor CT2108A 1, employing enantioselective, oxidative dearomatization of alkynylbenzaldehydes and subsequent oxidative modification of the azaphilone core.
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Total Synthesis of Complex Molecules
8:00 AM-12:00 PM, Wednesday, August 22, 2007 BCEC -- 258A, Oral
Division of Organic Chemistry |
