Studies toward the asymmetric synthesis of the diazobenzofluorene FL-120B'

ORGN 667

Stephen S. Scully, ssscully@bu.edu and John A. Porco Jr., porco@bu.edu. Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, 590 Commonwealth Avenue, Boston, MA 02215
The epoxide-containing diazobenzofluorene FL-120B' was isolated from Streptomyces Chattanoogensis in 1994 and was found to exhibit potent antibacterial activity. Recently, the closely-related natural product kinamycin C was synthesized in our laboratory. In this talk, we will review our studies towards the synthesis of FL-120B'which features new annulation strategies for installation of the critical diazo moiety.

 

Total Synthesis of Complex Molecules
8:00 AM-12:00 PM, Wednesday, August 22, 2007 BCEC -- 258A, Oral

Division of Organic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007