Chemical "sensing" using rapid separations

ANYL 331

Robert T. Kennedy, rtkenn@umich.edu, Department of Chemistry, University of Michigan, 903 N. University, Ann Arbor, MI 48109-1055
Fast electrophoresis and chromatography has enabled many new applications of these separations. We have explored rapid separations as a tool for chemical monitoring in complex environments. Successful development of this application requires integration of sampling, sample preparation, separation, and detection components. Microfabricated fluidic systems have made such integration much easier and more reproducible. We will describe recent progress in using such systems for monitoring neurotransmitters in vivo. New sampling approaches and methods for improving temporal resolution will be described. Other possible applications of this approach include process monitoring, chemical reaction monitoring, and rapid clinical assays.