ORGN 115 |
| The conformational properties of oligomeric ring-constrained gamma-amino acids have been examined in solution (predominantly by NMR in organic solvents), and in the solid phase by X-ray studies. This has demonstrated that conformation is dependant upon the ring size of the backbone constraint. Cyclopropane gamma-peptides adopt an extended structure and assemble into sheet structures stabilized by intermolecular C-H…O hydrogen bonds; this motif may also be used to design hairpin turn structures. In contrast, oligomers with a five or six-membered backbone constraints populate well-defined bend-ribbon type conformations stabilized by intramolecular hydrogen bonds in solution. |
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Total Synthesis, Materials, Devices and Switches, Molecular Recognition and Self-Assembly, Biologically-Related Molecules and Processes
8:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |