ORGN 194 |
| Previously, we reported the irreversible hydrogelation behavior of an amphiphilic aromatic electron donor-acceptor oligomer utilizing alternating leucine and aspartic acid linkers. We have now synthesized and fully characterized a series of these amphiphilic foldamers by substituting valine, isoleucine, and norleucine in place of leucine. The hydrogel characteristics, including the elasticity and charge-transfer absorbance, follow a trend of hydrophobicity of the side chains. Further characterization suggests additional order within the hydrogel and a fibrillar structure. The results have provided insight into the kinetic and thermodynamic landscape of the hydrogelation process mirroring the conformational switching of amyloid proteins. |
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Total Synthesis, Materials, Devices and Switches, Molecular Recognition and Self-Assembly, Biologically-Related Molecules and Processes
8:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |