ORGN 290 |
| During the past century, organic chemists carried out reactions and studied reaction mechanisms using macroscopic apparatus. Although there have been significant progresses in finding new reactions and understanding mechanisms, these macroscopic settings and their associated operation techniques have barely changed. Microfluidic devices, a special category of micromachines, exhibiting intrinsic advantages of reagents economy, control precision, high throughput, scalability and digital controllability are an emerging technology for studying organic reactions at miniaturized fashion. In this presentation, I would like to introduce two new types of microfluidic devices for performing sequential syntheses of positron emission tomography (PET) imaging probes and parallel screening of an in situ click chemical library. These results constitute a proof of principle for conducting sequential and parallel reactions on the nanogram to picogram scale in an automated fashion. Recently, further integrated microfluidic devices capable of wider exploration beyond a single application in monolithic devices are under development.
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Chemistry of the Mechanical Bond and Beyond
8:00 AM-12:00 PM, Monday, August 20, 2007 BCEC -- 253 A/B/C, Oral
Division of Organic Chemistry |
