ORGN 49 |
| Most methods for the intramolecular cyclization of epoxy alcohols to form tetrahydropyran rings electronically modify the epoxide to favor the desired regioisomer. Recently we have found that benzylidene acetals direct the desired endo cyclization without the need for biasing the epoxide in this fashion. Details of this transformation and a discussion of its potential application to the synthesis of polyether natural products will be presented.
|
|
New Reactions and Methodology
8:00 AM-12:00 PM, Sunday, August 19, 2007 BCEC -- 258B, Oral
Division of Organic Chemistry |
