INOR 8 |
| We have found that chiral Pd aqua complexes [Pd(ligand)(H2O) 2]X2 and binuclear Pd µ-hydroxo complexes [Pd(ligand)(OH)] 2X2 (ligand = BINAP or SEGPHOS derivatives) work as mild Brønsted acid and base catalyst. By using these complexes the chiral Pd enolates were generated from the carbonyl compounds and reacted with various electrophiles activated by a proton under acidic conditions. Highly enantioselective Michael addition, Mannich-type reaction, aldol reaction, and fluorination, have been achieved. Pd-catalyzed addition of amines or hydride to α, β-unsaturated carbonyl compounds generating Pd enolates was also found to proceed enantioselectively. |
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Frontiers in Organometallic Chemistry
8:25 AM-12:00 PM, Sunday, August 19, 2007 BCEC -- 206 A/B, Oral
Division of Inorganic Chemistry |