ANYL 121 |
| Novel biosensors are always needed for improving modern medical diagnosis and biomedical research, as well as the environmental and forensic sciences. Not surprinsingly, considerable attention has recently been focused on the development of novel tools for the specific, sensitive, rapid, and cost-effective detection of DNA, RNA, proteins, or other biomolecules. Some optical and electrochemical biosensors based on conjugated polymers have been recently proposed and succesfully applied for the detection of several important biological targets such as DNA, RNA, and proteins. In this presentation we will focus on a water-soluble cationic polythiophene derivative that can easily transduce oligonucleotide hybridization with a specific 20-mer capture probe into a clear optical (colorimetric or fluorimetric) output. Molecular dynamics simulations have been carried out to study the conformational structures and different interactions involved in the detection mechanism of this specific biosensor. |
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General Posters
7:00 PM-9:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Analytical Chemistry |